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Spinal Cord Injury Articles Posted by Manouli

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    StemCells, Inc. Transplants First Participant in Phase II Clinical Trial in Cervical Spinal Cord Injury
    Pathway Study to Assess the Potential of Human Neural Stem Cells to Restore Motor Function
    5 0 0 99 /news-release/2014/12/18/692474/10112873/en/StemCells-Inc-Transplants-First-Participant-in-Phase-II-Clinical-Trial-in-Cervical-Spinal-Cord-Injury.html?print=1 /news-release/2014/12/18/692474/10112873/en/StemCells-Inc-Transplants-First-Participant-in-Phase-II-Clinical-Trial-in-Cervical-Spinal-Cord-Injury.html?print=1
    December 18, 2014 08:00 ET | Source: StemCells, Inc.

    NEWARK, Calif., Dec. 18, 2014 (GLOBE NEWSWIRE) -- StemCells, Inc. (Nasdaq:STEM), a world leader in the research and development of cell-based therapeutics for the treatment of disorders of the central nervous system, announced today that it has transplanted the first subject in its Phase II Pathway? Study assessing the efficacy of its proprietary HuCNS-SC? (purified human neural stem cells) platform technology for the treatment of cervical spinal cord injury (SCI). The transplant was performed at the University of Miami Hospital within the Miller School of Medicine, home to The Miami Project to Cure Paralysis, one of the world's most comprehensive spinal cord injury research centers dedicated to finding effective treatments for paralysis.


      Trigger mechanism for recovery after spinal cord injury revealed
      ( After an incomplete spinal cord injury, the body can partially recover basic motor function. So-called muscle spindles and associated sensory circuits back to the spinal cord promote the establishment of novel neuronal connections after injury. This circuit-level mechanism behind the process of motor recovery was elucidated by Prof. Silvia Arber's research group at the Biozentrum, University of Basel and the Friedrich Miescher Institute for Biomedical Research. Their findings may contribute to designing novel strategies for treatment after spinal cord injuries and have now been published in the journal Cell.

      Spinal cord injuries often lead to chronically impaired motor function. However, patients with incomplete spinal cord injury can partially regain their basic motor ability under certain circumstances. It is believed that remaining uninjured spinal cord tissue provides a substrate to form new circuits bridging the injury. How this formation of new connections is triggered and promoted has remained unclear until now.



        December 2014 Last updated at 19:58 ET

        Drug can repair spinal cord injuries, study shows
        By James Gallagher Health editor, BBC News website
        A drug that can encourage nerves in the spinal cord to grow and repair injuries has been developed by US scientists.
        The study on rats, published in the journal Nature, showed some degree of movement and bladder control could be restored.

        The drug works by disrupting the "sticky glue" that prevents nerve cells from growing during an injury.
        Further tests still need to take place, but the charity Spinal Research said "real progress" was being made.
        Damage to the spinal cord interrupts the constant stream of electrical signals from the brain to the body.
        It can lead to paralysis below an injury.
        The team at Case Western Reserve University School of Medicine, in Ohio, said scar tissue that formed after an injury prevented spinal cord repair.
        Sugary proteins are released by the scar tissue which act like glue.
        The long spindly part of the nerve - the axon - gets trapped in the glue if it tries to cross the site of the injury.


          Here's a list of clinical trials:


            Bride Paralyzed in Crash Learns to Walk Down the Aisle for Wedding


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            12/29/2014 10:03 AM
            12/29/2014 10:12 AM
            TODAY) -- Even before she had a groom in mind, Katie Breland Hughes knew she wanted to walk down the aisle at her wedding on her own two feet.
            It became one of her initial goals after a horrific car accident left her paralyzed from the waist down. But first, she needed to survive her injuries.
            “Honestly, I had so many skin graft surgeries and so many burns, my first goal was just to sit up in the bed," said Hughes, now 27. "I was literally at rock bottom."
            In October 2011, the Louisiana personal trainer and physical therapy assistant missed a stop sign while driving home from an appointment with a client. A truck hit her vehicle broadside, and Hughes went flying through her windshield. She landed in a ditch and, seconds later, her burning car landed on top of her, searing her back.
            Conscious throughout the ordeal, Hughes knew she was either paralyzed or that her legs were amputated because she couldn’t feel either one.
            “Immediately, I started asking myself all the physical therapy questions. Is my spinal cord severed? What kind of injury is this? How far up? How low down?” she recalled for
            At the hospital, doctors told Hughes that she would never walk again. But during a nine-hour surgery to insert rods and plates along her spine to stabilize it, they learned that Hughes' spinal cord wasn’t severed as they originally thought.


              Rats with spinal injuries learn to urinate freely
              By Tim Sandle yesterday in Science
              Baltimore - Rats, in a new study, regained bladder control following a new treatment that coaxed severed nerves to grow back. It is hoped that the research can be applied to humans.

              Read more:


                Dr. Oz Show shares the Cristopher Reeves foundation newest spinal cord breathrough

                Anyone have anything to say about this? Seems to be promising..

                Four young men who have been paralyzed for years achieved groundbreaking progress ? moving their legs ? as a result of epidural electrical stimulation of the spinal cord. New research published in the medical journal Brain documents the effectiveness of epidural stimulation as a therapy option for chronic motor complete spinal cord injuries. The study was funded in part by the Christopher & Dana Reeve Foundation.




                  Trigger resource for liberation after spinal cord damage revealed
                  Dec 21, 2014
                  After an deficient spinal cord injury, a physique can partially redeem simple engine function. So-called flesh spindles and compared feeling circuits behind to a spinal cord foster a investiture of novel neuronal connectors after injury. This circuit-level resource behind a routine of engine liberation was elucidated by Prof. Silvia Arber’s investigate organisation during a Biozentrum, University of Basel and a Friedrich Miescher Institute for Biomedical Research. Their commentary might minister to conceptualizing novel strategies for diagnosis after spinal cord injuries and have now been published in a biography Cell.


                    Spinal Cord Injury - New York NY (Clinical Trial # 27937)
                    City: New York State: NY Zip Code: 10029 Study summary: The path to recovery from spinal cord injury (SCI) is full of challenges.

                    If you’re interested in taking part in research to evaluate investigational therapies for SCI, you may be interested in a clinical research study called Pathway that is evaluating the potential of neural stem cells to treat cervical spinal cord injury (cSCI).


                      Thursday, 01 January 2015
                      'Use it or lose it' treatment for spinal injuries
                      ⦁ /topics/health-a-medicine/item/3229-use-it-or-lose-it-treatment-for-spinal-injuries?tmpl=component&print=1
                      Written by Tony Malkovic
                      WEST Australian researchers are taking part in an innovative 'use it or lose it' approach to treating spinal injuries, with the potential to revolutionise the way such injuries are treated.
                      Three randomised control trials are underway as part of a multi-million dollar research project involving the University of WA, eight spinal units in Australia and New Zealand, and more than 300 patients with paraplegia or quadriplegia.
                      The trials aim to assess the impact of regular training or exercise—as soon as possible after spinal injury—on the regeneration of damaged nerves and outcomes of subsequent treatment.
                      Professor Sarah Dunlop, Head of UWA's School of Animal Biology and lead of the WA arm of the Spinal Cord Injury and Physical Activity (SCIPA) research project, says the physical training aims to return the body to its best possible condition for subsequent therapy.


                        Are electric shocks the key to curing paralysis? Groundbreaking experiment allows man to move his knee and toes for first time since he was paralysed in crash
                        ⦁ Method offers hope to thousands of people left paralysed by spinal injuries
                        ⦁ It involves giving the spinal cord an electrical stimulation
                        ⦁ Scientists say this 'teaches' the spinal cord to control limbs and body
                        By Mark Prigg For
                        Published: 15:55 EST, 6 January 2015 | Updated: 16:12 EST, 6 January 2015

                        Read more:
                        Follow us: @MailOnline on Twitter | DailyMail on Facebook


                          Tiny worm could lead to nerve injury treatments

                          8 January 2015
                          A small transparent roundworm with the remarkable ability to self-heal may hold the secret to treating nerve injuries in humans.
                          In a study published today in renowned scientific journal Nature, University of Queensland scientists have discovered the molecular mechanisms that allow severed nerves in roundworms to fuse back together.
                          Project leader Dr Massimo Hilliard, from the UQ Queensland Brain Institute (QBI), said the findings provided hope for treating nerve injuries.
                          “This will now open new avenues to try to exploit this knowledge in other systems closer to human physiology, and hopefully move further towards solving nerve injuries,” Dr Hilliard said.
                          “We’ll now try to understand if a similar process occurs in vertebrates and, if it doesn’t, how we can use what we have learned from worms to make it happen and then scale it up towards humans,” he said.


                            Decoded: How the brain, spinal cord make us walk
                            January 12, 2015

                            Researchers from the Medical University of Vienna have identified the mechanisms used by the spinal cord to trigger activity in leg muscles, marking the first time that the spinal cord activation patterns responsible for walking have been successfully decoded.
                            Previous research has demonstrated that this activity can be triggered in the leg muscles, even in patients suffering complete spinal paralysis, through the use of an implanted stimulator. Now, the new study identifies the mechanisms used by the spinal cord to control this activity, which still work even if the neural pathways from the brain are damaged due to an injury to the spinal cord.
                            Simon Danner of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna (MedUni Vienna) and an international team of colleagues explain in the journal Brain that paraplegics still have neural connections (also known as locomotion centers) below the site of the injury and these can trigger rhythmic movements in the legs.
                            “Using statistical methods, we were able to identify a small number of basic patterns that underlie muscle activities in the legs and control periodic activation or deactivation of muscles to produce cyclical movements, such as those associated with walking,” Danner said in a statement. “Just like a set of building blocks, the neural network in the spinal cord is able to combine these basic patterns flexibly to suit the motor requirement.”



                              Health & Medicine, News, Science

                              Paralyzed rats regain use of hind legs with flexible spinal cord implant. Humans to follow

                              Swiss scientists demonstrated a flexible ribbon-like implant that attaches itself to a paralyzed rat?s spinal cord, allowing the animal to walk again. The prosthetic, described by foremost experts in the field as ?remarkable?, works by delivering timed electrical impulses and drugs along the spinal cord. In this particular case, rats aren?t that different from humans, and true enough clinical trials are now one step closer. In the future, paralysis might just be another word for ?walking funny.?


                                Major Discovery on Spinal Injury Reveals Unknown Immune Response
                                Finding points to new treatments for trauma, neurodegenerative diseases
                                Released: 22-Jan-2015 8:45 AM EST
                                Source Newsroom: University of Virginia Health System

                                Citations Journal of Clinical Investigation, Jan-2015
                                Newswise — In a discovery that could dramatically affect the treatment of brain and spinal cord injuries, researchers have identified a previously unknown, beneficial immune response that occurs after injury to the central nervous system. By harnessing this response, doctors may be able to develop new and better treatments for brain and spinal cord injuries, develop tools to predict how patients will respond to treatment, and better treat degenerative conditions such as Alzheimer’s disease, multiple sclerosis, glaucoma and Lou Gehrig’s disease.
                                The newly discovered immune response occurs independently of the process that typically goads the immune system into action. In that process, the body identifies and attacks substances known as antigens, such as bacteria and viruses. “What we have shown is that the injured central nervous system talks to the immune system in a language that hasn’t been previously recognized in this context,” said Jonathan Kipnis, PhD, professor in the Department of Neuroscience at the University of Virginia School of Medicine and director of the Center for Brain Immunology and Glia. “It sends ‘danger signals’ and activates the immune system very rapidly. These danger signals cause immune cells to produce a molecule called interleukin 4, which happens to be indispensable for immune mediated neuroprotection after CNS trauma.”