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Paraplegic move legs after stem cell procedure- Brazilian Center of Cell Theraphy

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    Paraplegic move legs after stem cell procedure- Brazilian Center of Cell Theraphy

    I couldn't find this news in English. I'll try to translate a section of the today headline news from the Brazilian Center of Cell Therapy of Hospital Saint Rafael. This is one of the Brazilian top research centers.
    This English article is from last year and gives some details about the procedure when was done on animals http://www.cbtc-hsr.org/en/art.php?i...9kTGKxPm8GTk8=


    Paraplegic move legs after stem cell procedure

    A 47 year paraplegic legs and foot sensibility and movement came back after a experimental stem cell experiment. The treatment is based on the mesenchymal stem cells that are removed from the hip bone from the patient, separated and enriched in a solution of hormones and vitamins and implanted at the spinal cord.
    The first patient was a police men that is paraplegic for the last nine years after a fall that caused lumbar SCI. The patient started to fell his legs and foot six weeks after the stem cell procedure. And also started to control his bladder allowing him to stop Urinary Catheter Care.

    Portuguese Article
    Paraplégico mexe pernas após terapia com células-tronco

    Não se sabe se ele vai voltar a andar; paciente de 47 anos foi submetido a tratamento em fase experimental

    Pesquisadores na Bahia estão implantando células-tronco adultas em voluntários com lesão na medula

    GRACILIANO ROCHA
    DE SALVADOR

    Um paraplégico de 47 anos voltou a ter sensibilidade nas pernas e nos pés e a movimentar os membros inferiores após ser submetido a tratamento experimental à base de células-tronco, na Bahia.
    Desenvolvido por cientistas do Centro de Biotecnologia e Terapia Celular do Hospital São Rafael, em Salvador, e da Fiocruz, o tratamento consiste na retirada de células-tronco adultas do osso da bacia e no reimplante no local da lesão.
    O primeiro paciente, um policial militar de Salvador cuja identidade foi preservada, ficou paraplégico há nove anos, após uma queda que traumatizou a coluna na região lombar.
    Seis semanas após a implantação de células-tronco adultas no local da lesão, o paciente já voltou a sentir as pernas e os pés.
    Ele iniciou fisioterapia para fortalecer os músculos que ficaram muito atrofiados após o longo período de inatividade.
    A bióloga Milena Soares, que participa do projeto, é cautelosa ao prever se o paciente voltará a andar um dia.
    Segundo ela, isso vai depender, sobretudo, da fisioterapia. "Ele já consegue fazer alguns movimentos com a perna, e os resultados já mostram avanços muito significativos para a qualidade de vida do paciente", diz.
    Os pesquisadores afirmam que houve um aumento do controle da bexiga e do esfíncter. Com isso, o paciente ficará livre de cateterismos diários feitos para retirar urina.
    "Houve uma resposta muito boa no pós-operatório. Quatro dias depois [da cirurgia], o paciente já demonstrou melhora", diz Marcus Vinícius Mendonça, neurocirurgião que integra o grupo.
    Nessa fase experimental, que visa atestar a segurança do procedimento, a técnica será aplicada em 20 voluntários. Dois deles receberam as células anteontem e ontem. O próximo fará o procedimento na semana que vem.
    Segundo Mendonça, características do pós-operatório verificadas no primeiro paciente, como ausência de dores neuropáticas (característica de lesões neurológicas), se repetiram nos outros dois pacientes.

    #2
    Interesting.
    "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

    Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

    Comment


      #3
      In the portuguese article they say the improvements started 4 days post surgery. I don't think the cells themselves are that fast...
      Don't ask what clinical trials can do for you, ask what you can do for clinical trials.

      Fenexy: Proyecto Volver a Caminar

      http://www.fenexy.org (soon in english too)

      Comment


        #4
        Think that lesions are not homogeneous so there might be areas were the gap might be small and faster to reconect.

        Comment


          #5
          It seems too good to be true... time will tell.
          I think the hospital is a serious one as it is part of an international network led by an italian one the "S. Raffaele Hospital" of Milan that is really a good one here.
          In God we trust; all others bring data. - Edwards Deming

          Comment


            #6
            Let us wait and see more patients being treated.

            Lumbar injury patients being recovered that is great news.

            Comment


              #7
              the group envolved is 100% serious.

              Comment


                #8
                I also saw this article/video. Unfortunately this is in portuguese too....

                http://g1.globo.com/bahia/noticia/20...-na-bahia.html

                Arcy

                Comment


                  #9
                  Another legitimate clinical trial to add to the list it seems.

                  At least this time it is not intravenous or intrathecal administration of bone marrow stem cells which has been done to death. It would be interesting to find out more about their transplant techniques.

                  Comment


                    #10
                    Dear Fly Pelican this looks encouraging to us specially lower injuries whom need neuronal replacement therapy. I remember Dr Wise said in a thread that mesenchymal stem cells can be used for neuronal replacement.

                    Comment


                      #11
                      the news from the second article posted by Arcy is more detailed and even more positive. the police man now have bladder and bowel control what he says is huge for him. and he can exercise by himself in a bike. seems that the muscle atrophy is preventing him to have more mobility so they are working on strengthing the muscles.

                      Comment


                        #12
                        I recently met with the Provost of the University of Sao Paulo. This is the biggest and most prestigious university in Brazil. He tells me that they are very serious of both stem cell research and spinal cord injury. We will be working with them in the coming months and years.

                        The Brazilians were amongst the first in the world to do autologous bone marrow cell transplants for spinal cord injury over ten years ago. They also have a huge number of spinal cord injuries in Brazil both from traffic accidents and gunshot wounds.

                        I believe that Brazil will be an important player in the regenerative medicine field in the coming years, particularly since its economy has now stabilized that the influx of oil revenues to allowing the country to invest in medicine and science as never before in its history.

                        Wise.

                        Comment


                          #13
                          Nice to hear from you dear Wise.

                          Well what u think these mesenchymal cells can cure lumbar injuries as this patient with L1 has recovered so much including bladder bowel?

                          Although it is first phase of trial but looks very encouraging for lower injuries.

                          Can this cure my bladder bowel and sexual function if i undergo trials Dr Young?

                          Comment


                            #14
                            Originally posted by Jawaid View Post
                            Nice to hear from you dear Wise.

                            Well what u think these mesenchymal cells can cure lumbar injuries as this patient with L1 has recovered so much including bladder bowel?

                            Although it is first phase of trial but looks very encouraging for lower injuries.

                            Can this cure my bladder bowel and sexual function if i undergo trials Dr Young?
                            what of higher injuried like c5-c6 and alike?

                            sex sounds good nearly forgot what that was

                            Comment


                              #15
                              Any news from Brazil?

                              Some one from brazil can find out more about the trial going on. How much patients have been treated yet?

                              Comment

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