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Scripps Research scientists develop new test for 'pluripotent' stem cells

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  • Scripps Research scientists develop new test for 'pluripotent' stem cells

    The diagnostic test enables accurate, rapid assessment of the quality of stem cell lines

    LA JOLLA, CA – "Pluripotent" stem cells—which have the potential to mature into almost any cell in the body—are being widely studied for their role in treating a vast array of human diseases and for generating cells and tissues for transplantation. Now, a team of Scripps Research Institute scientists has created a quality control diagnostic test that will make it much easier for researchers to determine whether their cell lines are normal pluripotent cells.

    The study was published in an online version of Nature Methods on March 6, 2011.

    "Many scientists are unhappy with the current gold standard for testing for pluripotency, called the teratoma assay," said Scripps Research molecular biologist Jeanne Loring, principal investigator of the study. "The teratoma assay requires animal testing and a time span of six to eight weeks before scientists can prove that they have a pluripotent stem cell line. In addition, this method is technically challenging and difficult to standardize."