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  • Dr Young any feedback on conference?

    Wise, can you give any feedback on the conference yesterday? It would be good to know what transpired and what the future might bring.

    Thanks in advance
    keeping on

  • #2
    Wise, any feedback on conference .We would all be interested in your feedback.

    keeping on

    Comment


    • #3
      Sorry, I have been in meetings for the past three days and have spent whatever time I have taking care of silly problems on the site. So, anyway, a lot has been happening.

      At the Stem Cell Summit Meeting in New York City, over 30 stem cell companies presented their products and progress, often by the CEO, CSO, or CFO of the company. Arnold Caplan began the conference by summarizing the state of MSC's (mesenchymal stem cells), the hot cell that everybody is now taking to trial and market. Geron talked about their human stem cell lines and their hope that these cells will eliminate rejection of transplanted cells and will restore function in CNS and other conditions.

      Almost all the companies had phase 3 or clinical stage products. These include Aldagen, Athersys, Osiris, and others. It is truly amazing. Last year, only Osiris had an approved product. Now dozens of companies have FDA approved or approvable stem cell products. Most of the companies are doing mesenchymal stem cells. But a number have innovative cells including Pathfinder cells, placental cells, autologous cells, and adipose stem cells.

      I spoke in the afternoon and Steven Huhns from StemCell Inc (Stanford University) announced their start of a stem cell trial for patients that are 6-8 months after injury. They are doing 2 ASIA A, 3 ASIA B, and 4 ASIA C patients with their fetal stem cell lines. I am sorry but I was up on the podium and could not take notes. The cells have already been shown to be safe in phase 1 studies in genetic neurodegenerative diseases. The trial will start in March 2011. They are injecting many millions of cells (I think >20 million) into the spinal cord.

      Wise.

      Comment


      • #4
        Originally posted by Wise Young View Post
        I spoke in the afternoon and Steven Huhns from StemCell Inc (Stanford University) announced their start of a stem cell trial for patients that are 6-8 months after injury. They are doing 2 ASIA A, 3 ASIA B, and 4 ASIA C patients with their fetal stem cell lines. I am sorry but I was up on the podium and could not take notes. The cells have already been shown to be safe in phase 1 studies in genetic neurodegenerative diseases. The trial will start in March 2011. They are injecting many millions of cells (I think >20 million) into the spinal cord.

        Wise.
        Thanks Wise.

        I wonder whether StemCells Inc could be a possible source for the neural stem cells you mentioned for future trials beyond UCB+Lithium? No doubt you guys discussed that ;-)

        Fly Pelican Fly

        Comment


        • #5
          wise, thank you for the feedback. Sound like a lot of things happening. Keep us abreast of human clinical trials and what we can look forward to.

          keeping on

          Comment


          • #6
            Originally posted by Fly_Pelican_Fly View Post
            Thanks Wise.

            I wonder whether StemCells Inc could be a possible source for the neural stem cells you mentioned for future trials beyond UCB+Lithium? No doubt you guys discussed that ;-)

            Fly Pelican Fly
            Yes, they are a potential source. We are holding a ChinaSCINet meeting on April 19 in Hong Kong to look at all the sources of cells that could be used.

            Wise.

            Comment


            • #7
              Dr Young - when you say that they are injecting millions of cells (20 million) into the spinal cord - is this at a single time or over a period of weeks or days? How many Millilitres would this be at a time? What would be the safest volume/quantity to inject into the spinal cord at a single time?

              Comment


              • #8
                Originally posted by CarlBarnardo View Post
                Dr Young - when you say that they are injecting millions of cells (20 million) into the spinal cord - is this at a single time or over a period of weeks or days? How many Millilitres would this be at a time? What would be the safest volume/quantity to inject into the spinal cord at a single time?
                They are injecting the cells in one operation. Regarding the safe dose of cells to inject into the spinal cord, we are testing that now in our Hong Kong trial. We started with 4 µliters injected four times above and below the injury site. Because the injections were made into the spinal cord above the injury site, we monitored the sensations and motor scores of the segment above the injury. To date, we have transplanted four patients with the 4 µliter injections and have found that it is safe. We have done two patients with the 8 µliter injections and, so far, it also appears to be safe. If the next two patients show no adverse effects of the injections, we will go to the 16 µliter injections.

                The Geron trial is injecting 25 µliters of cells four times above and below the injury site. That is of course much more than we are injecting. By the way, in China, Hongyun Huang and others have been routinely transplanting 35 µliters in the midline once above and once below the injury site. We are injecting the cells into the dorsal root entry zone at a 45 degree angle to avoid penetrating the dorsal and lateral columns, which carry proprioceptive and motor signals up and down the spinal cord.

                Wise.

                Comment


                • #9
                  Wise--Think that the below link shows a ligitimate method of getting stem cells into the spinal cord safely?


                  http://www.youtube.com/watch?v=eXO_ApjKPaI&feature=player_embedded

                  Comment


                  • #10
                    Wise, with all the type cells now being considered for therapies; which do you think have the best chance for recovery and why?

                    keeping on

                    Comment


                    • #11
                      Wise, you mentioned injections in China that are higher than you are tetsing.
                      ! what tyype of cells
                      2what kind of results
                      You also mentioned in reference to the stem cell summit that acertain type of cell wa being used now. what makes that cel so intriguing or interesting? Do you see your trials trying different cells in the future?

                      Thanks wise for all you do.

                      keeping on

                      Comment


                      • #12
                        Originally posted by keeping on View Post
                        Wise, you mentioned injections in China that are higher than you are tetsing.
                        ! what tyype of cells
                        2what kind of results
                        You also mentioned in reference to the stem cell summit that acertain type of cell wa being used now. what makes that cel so intriguing or interesting? Do you see your trials trying different cells in the future?

                        Thanks wise for all you do.

                        keeping on
                        Keeping on,

                        Hongyun Huang was transplanting fetal olfactory ensheathing glia. Please search for his work on this site.

                        Yes, we are always looking for the best therapy to use.

                        Wise.

                        Comment


                        • #13
                          Originally posted by 6 Shooter View Post
                          Wise--Think that the below link shows a ligitimate method of getting stem cells into the spinal cord safely?


                          http://www.youtube.com/watch?v=eXO_ApjKPaI&feature=player_embedded
                          6 Shooter, I don't think so. Until somebody comes out with convincing data that cells injected intravenously gets into the spinal cord and improve function, I think that the best method is to transplant the cells directly to the spinal cord. Many neurosurgeons are reluctant to do such operations and one of our goals is to find out the best way to do such surgery and whether it is safe. All these methods of injecting the cells through the skin are very unlikely to work and probably will not be as safe.

                          Wise.

                          Comment


                          • #14
                            Wise, I see you commented on Dr Huabg and his transplanting of th ecell sinto over 1000 pateints with spinal injuries. It appears that sensory feelings were increased to the patients but motor function was minimal. Can you comment on this and does your therapy have better potential in restoring function?
                            Thanks in advance.

                            keeping on

                            Comment


                            • #15
                              Originally posted by Wise Young View Post
                              6 Shooter, I don't think so. Until somebody comes out with convincing data that cells injected intravenously gets into the spinal cord and improve function, I think that the best method is to transplant the cells directly to the spinal cord. Many neurosurgeons are reluctant to do such operations and one of our goals is to find out the best way to do such surgery and whether it is safe. All these methods of injecting the cells through the skin are very unlikely to work and probably will not be as safe. Wise.
                              Actually, I was thinking of spraying the stem cells on the exposed cord, not via direct injection and not on the skin.

                              Comment

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