Announcement

Collapse
No announcement yet.

ChinaSCINet Update

Collapse
This is a sticky topic.
X
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    Originally posted by Isildur View Post
    Only when there is a positive attitude of collaboration. In this case is more like a confrontation (I just know more than you, mine is the truth. And I will teach everyone here you are wrong).
    exactly. almost like religion.

    Comment


      Thank you Dr. Young for also posting your thoughts on the pTEN research that is underway. The number of neuroscientists doing pTEN nerve research has greatly expanded. As a result, papers will be published and collaborations are already forming. In May 2009, just three years ago, Zhigang He's lab was the only lab in the world doing PTEN nerve research. According to PubMed, today there are more than 17 labs conducting this research. This list does not include several good labs in Europe also participating in this area of research. A growing number of researchers feel this research has the potential to provide answers to regeneration and as a result, grant requests are being reviewed and approved for funding. This is indeed an exciting area of research to follow!

      • Zhigang He – Harvard University
      • Oswald Steward - UCIrvine + 3 additional researchers (USCD)
      • Hans Kierstead – UC Irvine
      • Binhai Zheng – UC San Diego
      • Mark Tusznski – UC San Diego
      • Kai Liu – Hong Kong University
      • Mary Bunge – Miami Project, University of Miami
      • Wolfram Tetzaloff – University of British Columbia
      • Jerry Silver – Case Western Reserve University
      • Itzhak Fisher – Drexel University
      • Larry Recht and Jim Wiemann - Stanford
      • Doug Zochodne – University of Calgary
      • Kevin Park – Miami Project, University of Miami
      • Gary Westbrook – Vollum Institute
      http://spinalcordresearchandadvocacy.wordpress.com/

      Comment


        The beauty of this ch'ase thing is it will never fail - because it will never go to human trials. If Wise is wrong about this scar stuff, we'll know before too long - because he's testing his theories. In my mind Wise and Jerry Silver aren't even in the same business. One is in the business of trying to cure spinal cord injury. The other is in the business of philosophizing about potential cures and criticizing those who are actively trying to cure spinal cord injury. Cord blood and lithium may cure spinal cord injury. Speeches at Working to Walk, theories that never get tested, and internet trash talk will not cure spinal cord injury.
        Last edited by rjg; 24 Aug 2012, 4:04 PM.

        Comment


          Im inclined to agree with rjg on the trials issue. For all the ground breaking discoveries that are being thrown around and talked about there are very few human trials that are making fast paced progress. While I dont think that Youngs is the "one cure" hes getting the work done. At the very least if it fails, we know it doesnt work for sure now and also he has a trial network already set up. Again though, its sad to see such little clinical progress, especially when you consider we are almost in the year 2013. At this rate there will likely not be a cure in 40 years unless aggressive clinical trials are persued the way Young is persuing his. IMO that is, but opinions are like @#%$@&*%everyone has em

          I would like to add a side note though that I do think Jerry and other similar research is very compelling. I think there is real promise in it, I just wish it could progress faster
          T6 complete since 3/21/2012

          Comment


            Originally posted by jsilver View Post
            Yes by all means there is hope.

            SFN 2012 abstracts
            Program#/Poster#: 270.04/EE16
            Presentation Title: Chondroitinase ABC treatment at super-chronic injury states promotes respiratory motor recovery following C2 hemisection
            Location: Hall F-J
            Presentation time: Sunday, Oct 14, 2012, 4:00 PM - 5:00 PM
            Authors: *W. J. ALILAIN1, J. SILVER2;
            1Neurosciences, Metrohealth Med. Center/Rammelkamp Ctr. for Educ. and Res., CLEVELAND, OH; 2Neurosciences, Case Western Reserve Univ. Sch. of Med., Cleveland, OH
            Abstract: Most spinal cord injuries (SCI) are at the cervical level. This can result in disruption of bulbospinal inputs to phrenic motor neurons which innervate the diaphragm. This oftentimes results in the inability to breathe and the need for mechanical ventilation, severely diminishing the quality of life of those afflicted with the injury. In our laboratory we utilize a lateral C2 hemisection model of SCI which results in paralysis of the ipsilateral hemidiaphragm to study the anatomical and physiological changes which take place after cervical injury and explore strategies to restore function. A majority of studies have investigated treatments at acute stages, within 1 week of injury, to restore respiratory motor function. Since a majority of the human SC injured population is at chronic stages, it is necessary to investigate if these same strategies are still effective long after the initial injury. One cannot assume that treatments that are effective at acute stages will be equally as effective later on since a variety of untoward changes may occur over time. One strategy that has a well characterized positive regenerative/sprouting effects at acute stages is treatment with chondroitinase ABC (ChABC). ChABC breaks down inhibitory chondroitin sulfate proteoglycans (CSPGs) in the lesion scar and the perineuronal net (PNN) - which are upregulated immediately following injury and potently inhibit plasticity and regeneration. In the current study we found that ChABC treatment alone at “super” chronic stages - 1 and 1.5 years post injury - can, indeed, restore hemidiaphragmatic function. Additionally, our data suggests that the restored function is greater than that which returns after acute treatment. Overall, this data suggests that at super-chronic injury states CSPGs and the PNN are still present and inhibitory to endogenous mechanisms to restore function. However, when enzymatically removed with ChABC alone, there is an enhanced response compared to acute treatment, further suggesting that precisely targeting CSPGs may be an important priority even in chronic SCI patients.
            Disclosures: W.J. Alilain: None. J. Silver: None.
            Keyword(s): SPINAL CORD INJURY
            PLASTICITY
            RECOVERY
            Support:
            Good news everybody - Dr. Silver is going to give a speech! I bet he'll even take questions after the presentation. There may even be Powerpoint. And refreshments! I was starting to lose hope, but now I'm a believer.

            Speech
            ??????
            Cure!

            Comment


              Originally posted by rjg View Post
              Good news everybody - Dr. Silver is going to give a speech! I bet he'll even take questions after the presentation. There may even be Powerpoint. And refreshments! I was starting to lose hope, but now I'm a believer.

              Speech
              ??????
              Cure!
              You are an idiot.

              Comment


                Kai Liu discovered the PTEN deletion in 2009 and now these guys are lloking at it? Yamanaka discovered iPS cells in 2007, and Dezawa discovered MUSE cells last year. Why does it seem like we are constantly playing catch up with the Asian scientists?

                Comment


                  Originally posted by BSgimp View Post
                  You are an idiot.
                  Personal attacks sting a bit less when they come from a guy who calls himself BSgimp.

                  Comment


                    Originally posted by havok View Post
                    Im inclined to agree with rjg on the trials issue. For all the ground breaking discoveries that are being thrown around and talked about there are very few human trials that are making fast paced progress. While I dont think that Youngs is the "one cure" hes getting the work done. At the very least if it fails, we know it doesnt work for sure now and also he has a trial network already set up. Again though, its sad to see such little clinical progress, especially when you consider we are almost in the year 2013. At this rate there will likely not be a cure in 40 years unless aggressive clinical trials are persued the way Young is persuing his. IMO that is, but opinions are like @#%$@&*%everyone has em

                    I would like to add a side note though that I do think Jerry and other similar research is very compelling. I think there is real promise in it, I just wish it could progress faster
                    Well said!
                    "I'm manic as hell-
                    But I'm goin' strong-
                    Left my meds on the sink again-
                    My head will be racing by lunchtime"

                    <----Scott Weiland---->

                    Comment


                      Originally posted by rjg View Post
                      The beauty of this ch'ase thing is it will never fail - because it will never go to human trials. If Wise is wrong about this scar stuff, we'll know before too long - because he's testing his theories. In my mind Wise and Jerry Silver aren't even in the same business. One is in the business of trying to cure spinal cord injury. The other is in the business of philosophizing about potential cures and criticizing those who are actively trying to cure spinal cord injury. Cord blood and lithium may cure spinal cord injury. Speeches at Working to Walk, theories that never get tested, and internet trash talk will not cure spinal cord injury.
                      one of your better posts.

                      Comment


                        Originally posted by rjg View Post
                        Good news everybody - Dr. Silver is going to give a speech! I bet he'll even take questions after the presentation. There may even be Powerpoint. And refreshments! I was starting to lose hope, but now I'm a believer.

                        Speech
                        ??????
                        Cure!
                        I love this one !
                        keep (rolling) Walking

                        Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

                        Comment


                          Originally posted by KofQ View Post
                          Kai Liu discovered the PTEN deletion in 2009 and now these guys are lloking at it? Yamanaka discovered iPS cells in 2007, and Dezawa discovered MUSE cells last year. Why does it seem like we are constantly playing catch up with the Asian scientists?
                          Our researchers at the Keck Center are currently learning to isolate MUSE cells from umbilical cord blood using a Fluorescence Activated Cell Sorter (FACS)- http://www.bio.davidson.edu/courses/...thod/facs.html
                          Our Postdoc student is soon going to Japan to learn from Dezawa. It's exciting.

                          Dr. Silver wouldn't be wasting time and money if he didn't believe in the science of Chase. Don't be absurd rjg.

                          Comment


                            I agree Tufelhunden. Discussion is great for all of us! I didn't realize that my question would cause such a stir. I was just wondering if I happened to be on the wrong side of the 50%.

                            Comment


                              Originally posted by Jim View Post
                              Our researchers at the Keck Center are currently learning to isolate MUSE cells from umbilical cord blood using a Fluorescence Activated Cell Sorter (FACS)- http://www.bio.davidson.edu/courses/...thod/facs.html
                              Our Postdoc student is soon going to Japan to learn from Dezawa. It's exciting.
                              Jim, thanks for posting this information. It's indeed an exciting area of research and we'll be following these developments along. Great news!
                              http://spinalcordresearchandadvocacy.wordpress.com/

                              Comment


                                Originally posted by Jim View Post
                                Our researchers at the Keck Center are currently learning to isolate MUSE cells from umbilical cord blood using a Fluorescence Activated Cell Sorter (FACS)- http://www.bio.davidson.edu/courses/...thod/facs.html
                                Our Postdoc student is soon going to Japan to learn from Dezawa. It's exciting.

                                Dr. Silver wouldn't be wasting time and money if he didn't believe in the science of Chase. Don't be absurd rjg.
                                The diagram makes it look more like a video game or Japanese cartoon that could cause seizures. Of course, I'm so desperate for some hope, I'll take it.

                                Comment

                                Working...
                                X