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  • Originally posted by moneymaker View Post
    Wise how much is needed to do phase 3?
    I am estimating that it will require about US$4 million in China and US$12 million in the U.S. Wise.

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    • Red Bull is a sponsor of SCI related projects, just a thought if you were looking for a big corporate sponsor.
      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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      • Originally posted by muskie View Post
        Red Bull is a sponsor of SCI related projects, just a thought if you were looking for a big corporate sponsor.
        Thanks, I will ask Jim Bennett to look into this. Wise.

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        • Red Bull are also working with Wings for Life, see more here https://www.facesforcharity.com/en/home.html

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          • this is small as compared what the Reeve foundation and the CIRM is getting. this seems out of kilter as to relevancy. I'm thinking if your trials show any efficay, money should be directed to you. Just my thoughts.

            Anthony

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            • Originally posted by keeping on View Post
              this is small as compared what the Reeve foundation and the CIRM is getting. this seems out of kilter as to relevancy. I'm thinking if your trials show any efficay, money should be directed to you. Just my thoughts.

              Anthony
              agree 100%
              www.MiracleofWalk.com

              Miracles are not contrary to nature, but only contrary
              to what we know about nature
              Saint Augustine

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              • Originally posted by muskie View Post
                Red Bull is a sponsor of SCI related projects, just a thought if you were looking for a big corporate sponsor.
                Muskie, do you know what other SCI related projects they support?

                Thanks,

                Jim

                Comment


                • Originally posted by Jim View Post
                  Muskie, do you know what other SCI related projects they support?

                  Thanks,

                  Jim
                  https://www.facesforcharity.com/en/home.html



                  http://www.wingsforlife.com/en/
                  keep (rolling) Walking

                  Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                  • http://www.wingsforlife.com/en-us/research/application/
                    We’re thrilled to announce that the Faces for Charity raised in total an incredible 1,000,000 Euros which will fund cutting-edge research projects around the globe.
                    The Wings for Life Spinal Cord Research Foundation is a privately funded research charity organisation with the exclusive aim to perform/promote basic and clinical research related to spinal cord injury. Research projects may address all aspects of spinal cord lesions, nerve regeneration, trophic support of lesioned neurons, and functional changes induced by lesions - preferentially in mammals. Proposals should have a view to translation from the laboratory to the clinical setting and have the potential to provide real benefits to human patients. Clinical research projects can be situated in the fields of diagnosis, acute lesion management including surgery, neurology, urology, rehabilitation, and other areas related to paraplegia.

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                    • Jim, I think JW got it covered.

                      Thanks JW
                      Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                      • Thanks

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                        • Red Bull owner donates EUR 70 million for SCI research

                          http://www.marca.com/2012/02/01/motor/formula1/1328091940.html
                          keep (rolling) Walking

                          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature

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                          • WISE, i'VE SAID THAt MY MEAGER CONTRIBUTIONs ARE GOINg TO YOU ANd YOUr TRIALS AS Of NOW. I belive in that you are the only one thus far and Stem Cell INc that are at a true study for repair for spinal cord deficiences at this. time. I repeat that I'm confounded as to why funds are not flowing in. CIRM and Miami Project and Reeve founation are loaded with funds and none at this are even close to a therapy. or trial. this forum has alowed us to discuss a cure/ Stem cell advances are coming fast for other ailments and I belive that more are coming. My hope is tha tyour UCBM and lithium will provide hope for CHRONICS,us on this forum, by showing real efficay and hope for us. Yes this forum has allowed us to exist with our ailments. Yes, we are not all alike. for me it has allowed me to exercise everyday for 4 hours/day. Yes I know my caregivers think I'm strong willed because of what they see me do everyday.Yes I see that a viable therapy will only be my hope to ever get to move my bowels, take a leak, and yes walk again. Your forum has provided hope and discussions for us on the cure thread. THIS HAS BEEN SIGNIFICANT FOR ALL OF US. I hope that funds will start to flow to you and we will soon see efficay. 2014 is a date in the futre but is an eternity for many of us.

                            anthony

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                            • Originally posted by Wise Young View Post
                              kz,

                              Spinal cord is different from a herniated disc. A disc is a piece of connective tissue and it doesn't matter if some cells die in the disc after the injection. Injecting into the spinal cord injury completely different. You don't want to kill any cells. Of course, some investigators have used the Seikagaku chondroitinase to treat rodent spinal cords but you need formal safety pathological analyses of the spinal cord under GLP (Good Laboratory Practice) conditions. I don't know (and don't think) that Seikagaku has "validated, proven, and established" the safety of the drug for administration into the spinal cord of rodents and a non-rodent species, as required by the FDA.

                              Wise.
                              So, would one only run a pathalogical analyses if you're preparing to take the enzyme to clinical trial then?

                              http://www.seikagaku.co.jp/english/pdf/84.pdf

                              May 10, 2012
                              Seikagaku Corporation
                              (Securities Code: 4548)
                              Kaken Pharmaceutical Co., Ltd.
                              (Securities Code: 4521)
                              Seikagaku and Kaken Conclude a Basic Distributorship Agreement
                              for SI-6603, Indicated for Treatment of Lumbar Disc Herniation
                              Seikagaku Corporation (Tokyo) and Kaken Pharmaceutical Co., Ltd. (Tokyo) hereby
                              announce that today they have concluded a basic agreement concerning exclusive
                              marketing rights in Japan for SI-6603 (generic name: condoliase), indicated for treatment of
                              lumbar disc herniation. The companies plan to execute a final agreement at the end of 2012.
                              Seikagaku is conducting clinical development of SI-6603 in Japan and the U.S. In Japan,
                              the development is in a stage of the Phase III clinical trial. Seikagaku aims to promptly
                              conduct this trial so as to obtain approval in the shortest possible time.
                              Characteristics of SI-6603
                              Lumbar disc herniation is the partial protrusion of the nucleus pulposus at the core of each
                              intervertebral disc or the anulus fibrosus, the disc’s outer layer. The resulting pressure on
                              spinal nerve root causes leg pain, back pain and discomfort. SI-6603 is an enzyme named
                              condoliase that specifically degrades glycosaminoglycans, which are the main components
                              of the nucleus pulposus. The injection of SI-6603 into the intervertebral disc would cause
                              reduction of the pressure on the nerves, resulting in relief from pain. Because SI-6603 does
                              not break down proteins, it is thought to have no effect on surrounding tissues, such as
                              blood vessels and nerves. Furthermore, a single injection treatment with SI-6603 is
                              expected to be as effective as lumbar disc surgery in alleviating symptoms, which means
                              that patients would also be possible to reap benefits in the form of the patient’s physical load
                              and reduced medical costs, including surgical and hospitalization costs.


                              Last edited by GRAMMY; 06-19-2012, 10:43 AM.
                              http://spinalcordresearchandadvocacy.wordpress.com/

                              Comment


                              • I am sure that i saw in one of his post (I hope i am not wrong ,sorry it was a while ago and i could not find that post , if somebody can find that , please post it here again) , Dr. Silver was saying about the safety of CHAS' and he said " it is soooo safe" .My understanding is that Dr. silver has been working with CHAS' for a long time and he must have a good records and documenations about the saftey of CHAS' on animals in order to believe that CHAS' is safe .
                                Dr. silver would you please explain about the safety of CHAS' and please correct me if i am wrong that you believe that CHAS' is safe (sorry if i am wrong about your safety statment , it was a while ago that i read that ). thanks

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