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    A sudden Lithium hype? The trials have not conclude anything yet, hopefully no one get overdosed by it.

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      Originally posted by Tyran21 View Post
      A sudden Lithium hype? The trials have not conclude anything yet, hopefully no one get overdosed by it.
      I know what you mean

      Alot of us are limited by pain. I've met paraplegics who say they don't feel any neuropathic burning, stinging, stabbing or shooting pain. It's a real downer for me, as I feel like I could have done so much more if it were not only for the horrible pain, but the EFFECTS of Lyrical/Pregabalin (600mg a day), Neurontin/Gabapentin (useless at even 1600mg or so a day), Amytriptyline (yes, for nerve pain funnily enough! Up to 50mg, some people take more). This is typically a daily dosage ( note, you MUST NOT take Pregabalin(Lyrics) and Gabapentin(Neurontin) at the same time. Ever. Apparently. Lol

      Aaaannnd others as needed such as oxynorm/oxycodone, oxycontin, codeine, paracetamol, tramadol, ibuprofen... I'm sure there are more (don't take anything until approved by your qualified and relevant doctor/consultant... I don't want to have a law suit, laa dee daa)

      You guys get the point. As a 20 year old I want to move on but am limited by pain and drugs. Some others are not (at least not to the same extent, and I'm sure there are plenty that are worse off)

      The hype is over solving most of the above. Lithium carbonate is already prescribed by a doctor... Except not for neuropathic pain, but for bipolarism. (Sorry if this isn't the correct term)

      The hype is that it's already available, and just need to prove or disprove that it's useful for treating pain.

      Regards

      Comment


        Originally posted by 6 Shooter View Post
        Lithium can be toxic if taking too much. The recommendation is to get a blood test 1 week into taking lithium then adjust up or down to get to the correct blood serum level. Don't recall what is the correct level at this point. Wise knows and posted about 5 years ago.
        I am not going to post the method to take lithium because it should only be prescribed and monitored by an experienced Dr. I will say that in the clinical trial, blood levels are tested after 3 days.

        If I was suffering with severe neuropathic pain and nothing else worked, I would look for a experienced Dr to prescribe and monitor. It's worth a shot, especially because you only have to take for 6 weeks.

        Comment


          image

          Originally posted by Jim View Post
          I don't recall the breakdown of paras/quads but there were several quads in the trial.

          "Involuntary walking," isn't accurate because the subjects must initiate stepping. Once they get going it becomes somewhat involuntary in a rhythm/flow sense but I wouldn't describe it as involuntary.

          Attached is a graphic of the Kunming Locomotor Scale so you have an idea what the rolling walker looks like and what the different stages are. The person in the graphic was not a subject in the trial.

          [ATTACH]55582[/ATTACH]

          where did you find this image? is it from this clinical trials?

          Comment


            Originally posted by Jim View Post
            There are 2 trials.

            CN302 Lithium for Neuropathic Pain
            As the CN102a study suggested the effect, this trial is to evaluate the efficacy of lithium in treating neuropathic pain in patients with spinal cord injury. This trial is ongoing and 1/2 of the subjects are reporting that their pain is gone.

            CN102b_KM: UCBMC Transplant with Rehabilitation Trial 15 of the 20 subjects in this trial are able to walk using a upper body supporting rolling walker. 2 of the 15 are able to walk using a four point walker. Bowel and bladder improvement has also been reported. A phase III clinical trial is now being planned for mid 2015 in China, India, US, & Norway-

            [ATTACH]55793[/ATTACH]


            so in this image you show as that the phase 3 will started at mid 2015 and it will takes 2 and half years? and then we will remain for the next papers and all this one year minimun???





            Comment


              Originally posted by athanasios View Post
              where did you find this image? is it from this clinical trials?
              No. They are not from the trial.

              Regards

              Comment


                Jim,
                If you are expecting the paper to be published by the end of the year, why is it going to take until the middle of next year to get the Phase III trial going?

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                  To all I am planning on making the trip to see Wise this Friday, maybe some of you have better questions then I am thinking of asking.. If there are let me know and I will gladly ask them.

                  Comment


                    jfreg, please keep us informed about your meeting with Dr. Wise.

                    Comment


                      I will gladly report what I find out,

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                        Hey, thanks for your gesture, but isn't it easier asking questions in this tread instead? Dr. Wise is one of the Admins and I'm sure that he'd be glad to answer clearly in writing any questions you may have.

                        I'd like to know your impression and thoughts after the event


                        Cheers
                        "Talk without the support of action means nothing..."
                        ― DaShanne Stokes

                        ***Unite(D) to Fight Paralyses***

                        Comment


                          Originally posted by Moe View Post
                          Hey, thanks for your gesture, but isn't it easier asking questions in this tread instead? Dr. Wise is one of the Admins and I'm sure that he'd be glad to answer clearly in writing any questions you may have.

                          I'd like to know your impression and thoughts after the event


                          Cheers
                          Maybe a basic question on here as in the past I find it hard to ask something clear, I will report..

                          Comment


                            It will take until mid-2015 to initiate the trial for three reasons. First, we have to obtain regulatory approval of the trials (called IND) and that approval will require the appropriate manufacturing of the cells. Second, the manufacturing of the cells has to be done in China and so we are busy training and setting up the facilities for doing that. We may have to do this in Taiwan, India, and Norway as well. Third, we have to raise the money for the trials. The trials will cost about $15 million.

                            Wise.

                            Comment


                              Any update you can share on the progress of the Stemcyte IPO?

                              Comment


                                Originally posted by Barrington314mx View Post
                                Any update you can share on the progress of the Stemcyte IPO?
                                Unfortunately, it will probably not happen until January 2015.

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