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  • "Stem Cell Spinal Cord Repair Within Five Years"

    http://www.aspenpost.net/index.php?s...earchbutton=Go

    I don't know how to paste the article here so you will have to follow the link.

  • #2
    Stem Cell Spinal Cord Repair ‘Within Five Years’
    January 29th, 2009

    ASPEN, COLORADO (Post Time News)—The lead researcher in embryonic stem cell therapies at the University of Colorado Denver School of Medicine is predicting that effective treatment to repair severed spinal cords with be available “within five years.”“This is really good news for people with spinal injuries,” Dr. Davies said.
    Speaking at the CU Given Institute here in Aspen, Dr. Stephen Davies—an associate professor of neurosurgery based at the sprawling Anschutz Medical Center in Denver—said his work in repairing scar tissue and growing neural connections between the brain and the spinal cord also has potentially profound applications for patients with Alzheimer’s, Parkinson’s disease, multiple sclerosis (MS), traumatic brain injury, and even diabetes. The key findings of Dr. Davis and his CU team—including his wife, Dr. Judith Davies—were published in the Journal of Biology online.
    Calling the results “remarkable,” Dr. Davies told the Aspen audience that within eight days and after just one treatment, 40 percent of rats with severed spinal cords were able to regain function undetectable from the uninjured rats in his experiment. He called the results a “robust effect” and “functional recovery.”
    The breakthroughs could impact the 450,000 people in the United States with spinal cord disabilities, with 11,000 new cases appearng each year in the U.S. alone. Some 81 percent of the victims are male, Dr. Davies said, with 52 percent under 30 years of age. Only 18 percent of the accidents causing the disability to occur during sports and recreation, with most emanating from motor vehicle accidents—and among those over 65.
    The key to the research is overcoming the barrier of scar tissue that grows in the spinal cord where the damage has occurred. In a nutshell, neurons in the brain send signals to other neurons in spinal chord; other sensory neurons also relay information and send it to the brain. This neural messages travel up and down the spinal chord.
    “How do we form a bridge at the injury site?” Dr. Davies asked the audience at The Given. “Which is the right cell type?”
    Nerve fibers are called “axons.” One key to the breakthrough are GLIA “glue” cells known as “astrocytes” or star cells. Dr. Davies called the astrocytes a “revolution in neuroscience.” Over ten years of research, he said his team developed a “micro injection system, “a Frankenstein-type experiment with adult neurons injected” into the spinal cords.
    The result? “Growing axons like gangbusters” in degenerated spinal cords or rats.
    Those axons are part of the reason the CU team has been able to bridge the formidable neurological barrier formed by scar tissue that forms quickly after the trauma and stops regeneration cold. For that reason, Dr. Davies said, his therapies will be far more effective immediately after injury, rather than on chronic spinal cord injury patients.
    Dr. Davies also said there were “clear differences between the embryo and the adult” stem cells in his research: an “immature central nervous system (CNS) can reestablish a connection,” he said, “until two to three days after birth.” Any stem cells taken later in the cycle cause a “sharp a cutoff in regeneration.”
    “Stem cell by definition can make all cells throughout the body,” he said, but adult “stem cells. are contributing to scar formation.”
    As for the controversy over using embryonic stem cells in research, Dr. Davies said on the “Con Games with Michael Conniff” radio show in Aspen that though his research deploys an embryonic stem-cell line approved in August 2001 by President George W. Bush, his team can now remove stem cells from blastocysts with further injuring the cell, presumably defusing any controversy.
    As of now, there are no treatments approved by the Federal Drug Administration (FDA) that can repair spinal cord injury. Once severed, paralysis and loss of function occurs, with the symptoms worsening the higher the trauma happened on the spinal cord.
    C-5, 6 SCI. Took about 6 months to walk. Walking full time. Without any assistance since Nov. 2003 and will make a full recovery

    Comment


    • #3
      In this article, Dr. Davies said, his therapies will be far more effective on immediate injuries rather than chronic????
      So this research also is only for acutes???
      I was under the impression that with all the support from here for his work that he was
      working towards a chronic therapy.
      Can someone enlighten me here, I am quite disappointed with his statement.

      Comment


      • #4
        Yay Dr. Davis!

        Comment


        • #5
          Originally posted by NancyR View Post
          In this article, Dr. Davies said, his therapies will be far more effective on immediate injuries rather than chronic????
          So this research also is only for acutes???
          I was under the impression that with all the support from here for his work that he was
          working towards a chronic therapy.
          Can someone enlighten me here, I am quite disappointed with his statement.
          Don't jump to conclusions. I think he is on his way with a result from studying chronic sci rats, I'm very much looking forward to learn what him & his team has to say.
          "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

          Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

          Comment


          • #6
            five years

            Damn I hope so, but FDA approval usually takes 5-10 years. Good news no matter what

            Comment


            • #7
              This is absolutely no reflection on the talented Dr. Davies. We have been told many times 5 more years to trials, McDonald, Heinrich Cheng, Vacanti Brothers, Bruhovetsky, Dr. Young, Darwin Prockop, Scott Falci, Raisman, and others I can't recall.

              Somehow things get in the way, get diverted, whatever. This hopefully will be great for acutes, but I'll believe it when I see it.

              Comment


              • #8
                Hopefully, with the Obama admnistration "believing" in the importance of science & research, things will move along a bit quicker.

                Comment


                • #9
                  Originally posted by rjames View Post
                  http://www.aspenpost.net/index.php?s...earchbutton=Go

                  I don't know how to paste the article here so you will have to follow the link.

                  oK. I have severed spinal cord. Where do I apply to be a rat?
                  http://stores.ebay.com/MAKSYM-Variety-Store

                  Comment


                  • #10
                    Exactly, I will take one of those apps?
                    I am existing right now, I would give anything to live again.

                    Comment


                    • #11
                      Originally posted by Schmeky View Post
                      This is absolutely no reflection on the talented Dr. Davies. We have been told many times 5 more years to trials, McDonald, Heinrich Cheng, Vacanti Brothers, Bruhovetsky, Dr. Young, Darwin Prockop, Scott Falci, Raisman, and others I can't recall.

                      Somehow things get in the way, get diverted, whatever. This hopefully will be great for acutes, but I'll believe it when I see it.
                      too true I was injured 6/05 & I've been hearing "5 more years" since then. It's so frustrating! Although I'm eternally grateful to those researchers that are working on a cure (especially given all the obstacles Bush made), sometimes I feel as though these Dr.s must think 5 years sounds like a tollerable amount of time to be paralyzed or something. I can't help being cynical at times..."like, yeah sure...you told him 5 more years 20 years ago."
                      On the other hand, the promise of a cure is the only thing that keeps me going.
                      www.christinasymanski.com

                      Comment


                      • #12
                        Originally posted by tskushi26 View Post
                        sometimes I feel as though these Dr.s must think 5 years sounds like a tollerable amount of time to be paralyzed or something
                        I think it has more to do with funding. There aren't very many
                        people who would feel motivated to fund research that could
                        take more than a decade to produce a therapy.

                        5 years sounds a lot more encouraging.

                        I remember in '06 when Missouri had a stem cell amendment on the
                        ballot. One of the arguments made by the opponents was that it could
                        take 15-20 years before stem cell research helped anyone, so don't
                        vote to fund it.

                        As a matter of fact, it was that asshole Kurt Warner who's playing
                        in the Super Bowl this year that made those exact remarks.

                        Comment


                        • #13
                          I wonder how much money do they need to give us the cure.


                          say, 200 million and 24 hours daily of study will give us the cure say in 3 years?

                          maybe some one will say I need this amount, and this amount of time, then I will deliver the cure. I wish the president ask Dr. Young, how much do you need and how long and Ill give it to you because I know in the long run the country will save a lot off millions yearly. But no no no no president will ask these simple questions and take an action. In every administration we never are the priority and that simply sucks. Maybe is our fault too for not know the right guys with the right positions.

                          I started playing the super ball lotto, and if I win all my money will go to cure us.


                          Anyone here knows how much money and time we need for fast results?


                          100 millions

                          200 millions

                          500 millions

                          1 billion? that's it, this will make us stand up.

                          2 billions this one for sure will make us take a few steps

                          3 billions we will not need it because by this amount we will be dead.

                          manouli.
                          Last edited by manouli; 01-31-2009, 12:47 AM.

                          Comment


                          • #14
                            Manouli,

                            I have been thinking a lot about this question ever since Obama won the election with $650 million raised from internet in less than a year. He did it not by having a couple of billionaires or even a couple hundred millionaires give him the money. He did it by convincing 30 million people to give him average of about $25.

                            We may not have 30 million who are sufficiently interested in giving $25 million apiece to spinal cord injury. However, I am convinced that we have at least 250,000 U.S. families with spinal cord injury who would be willing to give a dollar a day for clinical trials. That would be $91 million per year, enough to fund a couple of clinical trials.

                            Our dollar-a-day clinical trial program will do this. Perhaps as much or more than most, I have worked over the decades to raise money for spinal cord injury research and to lobby government to pay more for spinal cord injury research. This appraoch has not been and probably will not be enough. Why should anybody else give when most of us in the community will not.

                            When I first started doing spinal cord injury research 30 years ago (1979), I could not have imagined that our major obstacles to the cure would be money and politics. I thought that it would be the science. But, it has turned out to be politics and money for the last 8 years and probably just money for the next 4 years.

                            Due to the loss of confidence and the collapse of the credit industry, money is harder to get than a kiss from a stranger on the subway of New York. Foundations are struggling, governments are spending all their money on bailouts, and companies are into survival mode. In such an environment, the only way is to get a little bit of money from a lot of people.

                            Wise.

                            Originally posted by manouli View Post
                            I wonder how much money do they need to give us the cure.


                            say, 200 million and 24 hours daily of study will give us the cure say in 3 years?

                            maybe some one will say I need this amount, and this amount of time, then I will deliver the cure. I wish the president ask Dr. Young, how much do you need and how long and Ill give it to you because I know in the long run the country will save a lot off millions yearly. But no no no no president will ask these simple questions and take an action. In every administration we never are the priority and that simply sucks. Maybe is our fault too for not know the right guys with the right positions.

                            I started playing the super ball lotto, and if I win all my money will go to cure us.


                            Anyone here knows how much money and time we need for fast results?


                            100 millions

                            200 millions

                            500 millions

                            1 billion? that's it, this will make us stand up.

                            2 billions this one for sure will make us take a few steps

                            3 billions we will not need it because by this amount we will be dead.

                            manouli.

                            Comment


                            • #15
                              question

                              Dr. Young

                              when will start this program 1 dollar a day?

                              Comment

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