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  • why was this not available now as a treatment

    http://today.uci.edu/news/release_detail.asp?key=1058

    Blocking immune response to spinal cord injury can improve chances for recovery

    UCI researchers develop antibodies that lessen the severity of spinal cord injury


    Irvine, Calif., November 13, 2003
    People who suffer spinal cord injuries may have a greater chance of recovery if treated with drugs that block the body’s own immune response to the initial trauma, researchers from the Reeve-Irvine Research Center at UC Irvine have found.
    In addition, UCI neurologist Hans Keirstead and immunologist Thomas Lane have laid the foundation for these drugs by creating antibodies that, when tested on rats, stopped the secondary nerve and spinal cord damage caused by the immune system response. Use of these antibodies resulted in significantly improved rates of recovery.
    Previous studies have shown that the body’s immediate immune system response to a spinal cord injury actually worsens the condition. Results of this UCI study appear in the November issue of Experimental Neurology.
    “While the primary tissue damage caused by the initial spinal trauma cannot be reversed, we’ve discovered that the secondary damage caused by immune responses can be prevented, which gives those who suffer these injuries hope for recovery,” Keirstead said.
    Immediately after spinal cord trauma, cells called chemokines are released at the injury site and induce inflammation. One specific chemokine called CXCL-10 recruits immune system cells called T-lymphocytes. Normally, T-cells battle disease and other invading agents in the body, but in the central nervous system during spinal injury and periods of disease in multiple sclerosis, these T-cells create toxic compounds that attack and damage spinal tissue and nerve fibers.
    In tests on rats with induced spinal cord injuries, Keirstead and Lane treated one group with their antibody drugs that blocked CXCL-10 cells from recruiting T-cells to the injury site. Another group received no therapies. In the group treated with the antibodies, the researchers found a significant reduction in T-cell counts and spinal damage. The untreated rats showed increased T-cell levels and greater secondary tissue damage.
    In further tests 14 days after the initial injury, Keirstead and Lane found that the treated rats had far greater mobility than the untreated mice, suggesting that further tissue damage caused by T-cells can lead to increased paralysis.
    “The difference in mobility between the treated and untreated rats was dramatic,” Keirstead said. “It points to the necessity of treating people with antibodies immediately after their spinal cord injuries as part of both regular trauma care and their recovery program.”
    Rafael Gonzalez, Janette Glaser and Michael T. Liu of UCI assisted on the study, which was supported by the Roman Reed Spinal Cord Injury Research Fund of California, Research for the Cures and individual donations to the Reeve-Irvine Research Center.
    The Reeve-Irvine Research Center was established to study how injuries and diseases traumatize the spinal cord and result in paralysis or other loss of neurologic function, with the goal of finding cures. It also facilitates the coordination and cooperation of scientists around the world seeking cures for paraplegia, quadriplegia and other diseases impacting neurological function. Named for actor Christopher Reeve, the center is part of the UCI College of Medicine.
    Keirstead and Lane also are principals in Ability Biomedical Corp., a pharmaceutical development firm developing chemokine-based therapeutic drugs for treating spinal cord injury and multiple sclerosis. They recently created a human antibody based on the one used in this study to be used in future clinical trials. In 2001, the researchers found that the same antibodies used in this study were also effective in stopping and reversing nerve damage in multiple sclerosis triggered by T-cells.
    The University of California, Irvine is a top-ranked public university dedicated to the principles of research, scholarship and community. Founded in 1965, UCI is among the fastest-growing University of California campuses, with more than 24,000 undergraduate and graduate students and about 1,300 faculty members. The third-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3 billion.
    Last edited by jhope; 10-27-2008, 02:49 AM.
    Han: "We are all ready to win, just as we are born knowing only life. It is defeat that you must learn to prepare for"

  • #2
    Please tell me it doesn't say 2003..
    "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

    Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

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    • #3
      Yep, it does, and that's why the top trauma centers do this now.

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      • #4
        From what I understand it is in Phase 2 clinical trials right now for ulceratvie colitis and rhuematoid arthritis. These diseases were picked due to the fact they are easier to conduct clincial trials on, larger population than SCI, making it easier to secure funding. If trials are succesful it could be used "off label" in acute SCI. It has been shown to greatly reduce secondary damage in acute SCI.

        http://www.medarex.com look under "Pipeline" for MDX-1100 anti IP10

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        • #5
          I find it difficult not to get irrationally pist off these days, I think I had a gut feeling regarding this medicin.
          But to see in writing that there was something to stop the secondary damage developed 5 years prior to my accident not reaching the bedside... It's ... unbearable... Goddammit! How do we stop this from happening to new SCI wictims?
          How can this happen?
          Last edited by topperf; 10-25-2008, 05:19 PM. Reason: Clarification
          "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

          Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
          Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

          Comment


          • #6
            tip of the ice berg. there is a lot of treatments out there being witheld from us....

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            • #7
              Originally posted by DA View Post
              tip of the ice berg. there is a lot of treatments out there being witheld from us....
              DA why do you think thay would be keeping thing's from us
              AS I SIT HERE IN MY CHAIR . I LOOK OUT UPON THE GROUND .I WONDER WILL I EVER GET UP AND WALK A ROUND ??


              http://justadollarplease.org

              Comment


              • #8
                OK then.!! I am physicaly sick..!!!!!!!!!!!!!!!!
                "When it rains I am thankful I can feel the raindrops". Mr D. Wright

                "Tonight we dine in hell". Leonidas 300

                Comment


                • #9
                  Originally posted by skeaman View Post
                  DA why do you think thay would be keeping thing's from us

                  $$ What Else?
                  Shame soo many are too Stupid and Greedy to realize what truly matters in life.
                  "Only when its too late, do people understand....." (Most anyway.....)
                  ====================
                  If you stare long enough,
                  I may do a Trick....

                  Comment


                  • #10
                    Interesting....

                    Antibody "drugs" in general are quite pricey, but pennies compared to the cost of a spinal cord injury - both personally and financially.

                    But because they are so pricey, they will need to go through extensive clinical trials before it would be used routinely. And there will have to be a lot of pressure put on hospitals to keep such a medicine in stock near the emergency room so that it can be given in a timely manner.

                    The steroids that are often given to patients within 8 hrs of their spinal cord injury in theory work in a similar way (although not as specific/targeted) as this antibody treatment. They both work by trying to turn down your own body's exploding immune response following spinal cord injury that should be trying to repair damage, but which unfortunately sometimes causes damage on its own... Of course, one may work better then the other.....

                    Comment


                    • #11
                      Originally posted by topperf View Post
                      I find it difficult not to get irrationally pist off these days, I think I had a gut feeling regarding this medicin.
                      But to see in writing that there was something to stop the secondary damage developed 5 years prior to my accident not reaching the bedside... It's ... unbearable... Goddammit! How do we stop this from happening to new SCI wictims?
                      How can this happen?
                      I was livid when I read this also. How many have to suffer? Most of us could be half normal but no one believes urgency is necessary unless death is immanent. Well there are things worse than death. SCI is one of them.
                      Last edited by jhope; 10-27-2008, 03:00 AM.
                      Han: "We are all ready to win, just as we are born knowing only life. It is defeat that you must learn to prepare for"

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