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Urecholine dangers

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  • Urecholine dangers

    What cardiac and blood pressure side effects does urecholine possibly cause?
    Does it also cause breathing problems and lack of oxygen?
    When is it safe to use?
    What dose is safe to use?

  • #2
    I am taking 30mg urecholine. How much mg urecholine is considered safe to use with possibly no side effects?


    • #3
      What type/specific symptoms of cardiac and blood pressure problems does urecholine possibly cause?
      Does urecholine cause breathing problems, lack of oxygen, low/high blood pressure?
      I am taking 30mg urecholine. What amount is considered safe due to low dosage?
      Does urecholine cause irreversible damage?
      My urologist prescribed it to me after having 2 months urinary retention. I usually do well with reflex voiding based on my urodynamics indicating low voiding pressures and low urinary retention in past. I had hydronephrosis in my kidney once in an ultrasound test in past but have tested fine since in yearly ultrasounds. I took vital signs after taking urecholine in dr's office and was fine but i also decided to be monitored at emergency room after taking an additional dose that day because of all the negative stories on this website regarding urecholine and was fine in my vital signs. I have been getting low blood pressure, wheezing/difficulty breathing but im not sure if it is from my seroquel or urecholine. When i take urecholine alone, i have no trouble breathing. But when i take urecholine with seroquel together, thats when i have a hard time breathing. Even seroquel alone will cause me hard time breathing although i have been taking 30mg urecholine for about 2 1/2 months now.

      Please respond/answer in a very detailed way please.
      God bless you,


      • #4
        Do you have a spinal cord injury? If so, what level? What is your location (country, state, etc.)? A more complete profile makes it much easier to put your questions into context.

        Urecholine is rarely used now days. Reflex voiding as a bladder management method has also fallen out of favor, and is rarely if ever attempted in new injury patients as it was in the 1970s and 1980s. This changed when we learned of the importance of maintaining low/normal voiding or bladder pressures as a way to preserve kidney function over the long term. High pressures (generally defined as >40 Cm. H20) put back pressure on the kidneys, as these high pressures limit the ability for urine to flow under low resistance from the ureters into the kidney. Your previous experience with hydronephrosis can be one indication that you have high bladder pressures.

        Have you had recent urodynamics studies (usually a CMG combined with external sphincter EMG)? What was your PdetMax? Is your urologist as specialist in neurologic urology? How long have you been using reflex voiding? What is your residual urine amount?

        One of the reasons that reflex voiding is no longer recommended is that for many, the bladder, over time, becomes decompensated, meaning that it looses the power to contract either by bladder spasm or reflex voiding. This is not remedied by reducing sphincter resistance such as with medication or with surgical procedures (urethral stent or sphincterotomy). Have you ever had a sphincterotomy? Urecholine has been attempted as a treatment for this decompensation in some cases, although it is rarely effective.

        Here are the most common side effects of the use of Urecholine (bethanechol chloride, bethanechol):
        • dizziness,
        • drowsiness,
        • lightheadedness,
        • headache,
        • nausea,
        • vomiting,
        • abdominal cramps/pain,
        • diarrhea,
        • increased saliva or urination,
        • sweating,
        • flushing or warmth about the face,
        • watery eyes,
        • headache, or
        • slow heartbeats followed by fast heartbeats.
        • Belching
        • blurred vision or change in near or distance vision
        • diarrhea
        • redness or flushing of skin or feeling of warmth
        • seizures
        • sleeplessness,
        • nervousness, or jitters
        • Shortness of breath, wheezing, or tightness in chest
        The most serious of these are:
        • fainting,
        • fast heartbeat, or
        • Shortness of breath, wheezing, or tightness in chest
        There is no evidence that side effects persist after discontinuation of this drug.

        Dosage of bethanechol chloride is individualized, depending on the type and severity of the condition. The usual adult dose of bethanechol chloride ranges from 10 to 50 mg three or four times a day. Maximum dose is 50 mg. daily. Bethanechol chloride may interact with donepezil, tacrine, quinidine, or procainamide. Tell your doctor all medications you are taking.

        Drug-drug interactions of Urecholine with Seroquel have not been reported, but that is no guarantee that this could not occur. Respiratory distress or shortness of breath is a rarely reported side effect, although this can occur in conjunction with either very fast or very slow pulse rate. If you and your provider think that you are having an adverse side effect from either drug, or from a drug-drug interaction, they should submit an FDA report of this by calling 1-800-FDA-1088. It can also be reported by a clinical pharmacist.


        The SCI-Nurses are advanced practice nurses specializing in SCI/D care. They are available to answer questions, provide education, and make suggestions which you should always discuss with your physician/primary health care provider before implementing. Medical diagnosis is not provided, nor do the SCI-Nurses provide nursing or medical care through their responses on the CareCure forums.