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Treatment of spinal cord injury with mesenchymal stem cells

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    Treatment of spinal cord injury with mesenchymal stem cells

    Treatment of spinal cord injury with mesenchymal stem cells

    Ling Ling Liau,1 Qi Hao Looi,2 Wui Chuen Chia,2 Thayaalini Subramaniam,3 Min Hwei Ng,3 and Jia Xian Lawhttps://www.ncbi.nlm.nih.gov/corehtm...s/corrauth.gif3
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    Background


    Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.
    Results


    This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue.
    Conclusion


    These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510077/
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005
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