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Therapeutic repair for spinal cord injury: combinatory approaches

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    Therapeutic repair for spinal cord injury: combinatory approaches

    Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem

    Jarred M Griffinhttps://www.ncbi.nlm.nih.gov/corehtm...s/corrauth.gif 1 and Frank Bradkehttps://www.ncbi.nlm.nih.gov/corehtm...s/corrauth.gif 1
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    This article has been cited by other articles in PMC.
    Go to:Abstract


    The recent years saw the advent of promising preclinical strategies that combat the devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials. However, individually, these treatments produce only modest levels of recovery in animal models of SCI that could hamper their implementation into therapeutic strategies in spinal cord injured humans. Combinational strategies have demonstrated greater beneficial outcomes than their individual components alone by addressing multiple aspects of SCI pathology. Clinical trial designs in the future will eventually also need to align with this notion. The scenario will become increasingly complex as this happens and conversations between basic researchers and clinicians are required to ensure accurate study designs and functional readouts.


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059014/
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005
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