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Dissecting the Dual Role of the Glial Scar & Scar-Forming Astrocytes inSCI

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    Dissecting the Dual Role of the Glial Scar & Scar-Forming Astrocytes inSCI

    Front Cell Neurosci. 2020; 14: 78.

    Tuo Yang,1,2 YuJuan Dai,2 Gang Chen,3,4,* and ShuSen Cui1,*
    Author information Article notes Copyright and License information Disclaimer
    Go to:Abstract


    Recovery from spinal cord injury (SCI) remains an unsolved problem. As a major component of the SCI lesion, the glial scar is primarily composed of scar-forming astrocytes and plays a crucial role in spinal cord regeneration. In recent years, it has become increasingly accepted that the glial scar plays a dual role in SCI recovery. However, the underlying mechanisms of this dual role are complex and need further clarification. This dual role also makes it difficult to manipulate the glial scar for therapeutic purposes. Here, we briefly discuss glial scar formation and some representative components associated with scar-forming astrocytes. Then, we analyze the dual role of the glial scar in a dynamic perspective with special attention to scar-forming astrocytes to explore the underlying mechanisms of this dual role. Finally, taking the dual role of the glial scar into account, we provide several pieces of advice on novel therapeutic strategies targeting the glial scar and scar-forming astrocytes.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147295/
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005
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