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Acute neuromodulation restores spinally-induced motor responses after severe SCI

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  • Acute neuromodulation restores spinally-induced motor responses after severe SCI

    Exp Neurol. 2020 Feb 11:113246.

    Acute neuromodulation restores spinally-induced motor responses after severe spinal cord injury.

    Taccola G1, Gad P2, Culaclii S3, Wang PM3, Liu W4, Edgerton VR5.

    Author information
    Abstract
    Epidural electrical spinal stimulation can facilitate recovery of volitional motor control in individuals that have been completely paralyzed for more than a year. We recently reported a novel neuromodulation method named Dynamic Stimulation (DS), which short-lastingly increased spinal excitability and generated a robust modulation of locomotor networks in fully-anesthetized intact adult rats. In the present study, we applied repetitive DS patterns to four lumbosacral segments acutely after a contusive injury at lumbar level. Repetitive DS delivery restored the spinally-evoked motor EMG responses that were previously suppressed by a calibrated spinal cord contusion. Sham experiments without DS delivery did not allow any spontaneous recovery. Thus, DS uniquely provides the potential for a greater long-term functional recovery after paralysis.


    https://www.ncbi.nlm.nih.gov/pubmed/32057795
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005
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