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Recovery of locomotor function with combinatory drug treatments

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  • Recovery of locomotor function with combinatory drug treatments

    Curr Med Chem. 2009;16(11):1366-71.

    Recovery of locomotor function with combinatory drug treatments designed to synergistically activate specific neuronal networks.

    Guertin PA.

    Laval University Medical Center (CHUL - CHUQ), Neuroscience Unit, RC-9800, 2705 Laurier Blvd, Quebec City, Quebec, G1V 4G2, Canada. Pierre.Guertin@crchul.ulaval.ca.

    Spinal cord injury (SCI) is a devastating condition generally leading to a permanent and irreversible loss of sensory and motor functions. We have identified recently a number of serotonergic, adrenergic and dopaminergic receptor agonists or precursors that can acutely elicit some motor and locomotor-like movements in completely spinal cord-transected (thoracic level) animals. However, only partial central network-activating effects were found with single molecules since none administered separately could elicit weight-bearing and functional stepping movements in Tx animals. In turn, a recent breakthrough revealed that full spinal locomotor network-activating effects may be induced with synergistic drug combinations. Indeed, specific cocktails comprising some of these agonists and precursors were found, indeed, to powerfully generate weight-bearing stepping with plantar foot placement in untrained, non-assisted and non-sensory-stimulated Tx mice. This significant finding provides clear evidence suggesting that combinatorial approaches based on drug-drug synergistic interactions may constitute innovative solutions for the design and development of novel pharmacological therapies in the field of SCI and related neurological disorders.

    http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  • #2
    they didint name any drug or exercise.

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    • #3
      Imight, you can purchase the article here if you're interested in knowing the drugs used. Alternately, you could try emailing Dr. Guertin and asking him.
      ...it's worse than we thought. it turns out the people at the white house are not secret muslims, they're nerds.

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      • #4
        Originally posted by Steven Edwards View Post
        Imight, you can purchase the article here if you're interested in knowing the drugs used. Alternately, you could try emailing Dr. Guertin and asking him.
        yea I dont know about purchasing but it appears he's talking about raising the seratonin level and using dopamine. I guess that makes sense as one helps with focus and the other motor control. I took a lot of 5-HTP (raises seratonin) my first year. dunno how much it helped really, I stopped once I got 4AP, which appeared to work way better.

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