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Neugebauer (2001): Peripheral metabotropic glutamate receptors: fight the pain where it hurts

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    Neugebauer (2001): Peripheral metabotropic glutamate receptors: fight the pain where it hurts

    Trends in Neurosciences

    Volume 24, Issue 10 SummaryPlus
    1 October 2001 Article
    Pages 550-552 Journal Format-PDF (263 K)


    Research update


    Peripheral metabotropic glutamate receptors: fight the pain where it hurts

    Volker Neugebauer

    Dept of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, TX 77555-1069, USA

    Available online 21 September 2001.



    Abstract

    Recent anatomical and behavioral data show the expression of G-protein coupled metabotropic glutamate receptors in the periphery on nociceptive primary afferent nerve terminals, and provide evidence for a functional role of peripheral metabotropic glutamate receptors in inflammatory pain. These findings have important implications for new therapeutic strategies that target peripheral metabotropic glutamate receptors for pain relief. They also alert us to the necessity of assessing drug effects at different levels of the nervous system: peripheral and central.

    Author Keywords: pain; mgluR; inflammation

    Subject-index terms: Neuroscience


    Article Outline

    Anatomical evidence for peripheral mglu receptors
    Functional relevance of peripheral mglu receptors in normal nociception
    Functional role of peripheral mglu receptors in inflammatory pain
    Clinical implications and conclusions
    Acknowledgements
    References

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