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Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after SCI

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    Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after SCI

    Korean J Physiol Pharmacol. 2015 Mar;19(2):125-30. doi: 10.4196/kjpp.2015.19.2.125. Epub 2015 Feb 25.

    Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats.

    Kim J1, Kim Y2, Hahm SC1, Yoon YW2.

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    Abstract

    Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and the cholecystokinin type B antagonist CI-988 on below-level neuropathic pain after spinal cord injury in rats. We also examined the interaction of morphine and CI-988 in the antinociceptive effect. Both morphine and CI-988 given individually increased the paw withdrawal threshold to mechanical stimulation in a dose-dependent manner. The combination of ineffective doses of intrathecally administered CI-988 and morphine produced significant analgesic effects and the combination of effective doses resulted in analgesic effects that were greater than the sum of the individual effects of each drug. Thus, morphine showed a synergistic interaction with CI-988 for analgesia of central neuropathic pain.


    http://www.ncbi.nlm.nih.gov/pubmed/25729274
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

    #2
    Wtf?

    I'm sure the rat population is thrilled however we humans need something years ago. I have been a quadriplegic for 36 years and nothing significant in this area of staggering pain. Why? I just don't understand.....
    Last edited by craig; 11 Dec 2015, 4:55 PM. Reason: spelling

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