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MSC-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

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    MSC-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

    Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

    Mengtian Guo,#1,2 Zhenyu Yin,#1,2 Fanglian Chen,3 and Ping Leihttps://www.ncbi.nlm.nih.gov/corehtm...s/corrauth.gif1,2
    Author information Article notes Copyright and License information DisclaimerAssociated Data

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    Alzheimer’s disease (AD) has been a devastating public health with the development of global aging. Approaches for reducing the current AD epidemic are becoming a primary focus of human healthcare due to the lack of achieved lasting and complete remission strategies to treat AD with the characteristics of heterogeneity and complexity. Exosomes, which is the new emerging approach to intercellular communication, provide novel perspective on identified therapeutic strategies of AD. Mesenchymal stem cell-derived exosomes (MSC-exos) are emerging to be an appealing therapeutic tool for AD, with the donor-derived properties and the characteristics of minimal immunogenicity, effortless storage, nature delivery vehicles, and low risks of tumor formation based on the previous researches. In this review, we elaborate the mechanism of MSC-exos in the treatment of AD and discuss limitations in the clinical application.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488700/
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005
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