Neuroinflammation, Stem Cells, and Stroke
Stefan Anthony # 1, Dorothy Cabantan # 1, Molly Monsour # 2, Cesario V Borlongan 2
Affiliations expand
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window stands as an urgent need in stroke. The progressive inflammation that occurs centrally and peripherally after stroke serves as a unique therapeutic target to retard and even halt the secondary cell death. Stem cell therapy represents a potent approach that can diminish inflammation in both the stroke brain and periphery (eg, spleen), advancing a paradigm shift from a traditionally brain-focused therapy to treating stroke as a neurological disorder with a significant peripheral pathology. The purpose of this review article is to highlight the inflammation-mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses.
Keywords: blood-brain barrier; central nervous system; hemorrhage; inflammation; interleukin.
https://pubmed.ncbi.nlm.nih.gov/35380050/
Stefan Anthony # 1, Dorothy Cabantan # 1, Molly Monsour # 2, Cesario V Borlongan 2
Affiliations expand
- PMID: 35380050
- PMCID: PMC9038685 (available on 2023-05-01)
- DOI: 10.1161/STROKEAHA.121.036948
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United States and around the world. Accordingly, finding safe and effective novel treatments with a wider therapeutic window stands as an urgent need in stroke. The progressive inflammation that occurs centrally and peripherally after stroke serves as a unique therapeutic target to retard and even halt the secondary cell death. Stem cell therapy represents a potent approach that can diminish inflammation in both the stroke brain and periphery (eg, spleen), advancing a paradigm shift from a traditionally brain-focused therapy to treating stroke as a neurological disorder with a significant peripheral pathology. The purpose of this review article is to highlight the inflammation-mediated secondary cell death that plagues both brain and spleen in stroke and to evaluate the therapeutic potential of stem cell therapy in dampening these inflammatory responses.
Keywords: blood-brain barrier; central nervous system; hemorrhage; inflammation; interleukin.
https://pubmed.ncbi.nlm.nih.gov/35380050/