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Anti Biotic Resistance a hoax?

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    Anti Biotic Resistance a hoax?

    An organization called live UTi Free offered me information on a 2018 trial (link below) but i feel these trials might not apply to the SCi community

    This trial seems to try and debunk that anti biotic resistance can occur>

    excerpt in the below table:
    Antimicrobial resistance Patients with chronic recalcitrant bladder pain and recurrent cystitis can be diagnosed and treated, but at this time we have been unable to find a method that does not rely on the long-term use of urinary antibiotics given in full dose. This raises great concern because of the problem of antimicrobial resistance (AMR). Some advocate that such people should not be so treated for fear of threatening the rest of the population with a surge in further AMR. It seems unreasonable to penalise, in this way a small subset of mainly women who suffer from an extremely unpleasant disease, particularly when the key challenges are to be found in agriculture, China, the USA, Brazil and the Asian subcontinent.

    In recent times it has become clear that widespread multi-antibiotic resistance has predated humans by millions of years. This is not surprising, since the bacteria have been around for 3.5 billion years to evolve; antibiotics come from microbes which they generate to compete with other species and they have to co-evolve resistance factors or they must kill themselves. This also means that there are likely to be a wide variety of different resistance mechanisms, many as yet undiscovered. The current AMR crisis arises from the selection of resistance strains from the natural population through antibiotic use. If you stick to narrow spectrum first generation agents then you are bound to limit the resistance dispersion which is what we seek to achieve.

    Yanomami hunter-gatherers, isolated for 11,000 years, carry in their bowels microbes with numerous antimicrobial resistance genes including resistance to synthetic antibiotics. These tribes are so isolated that they have had no antibiotic exposure.

    A section of the Lechuguilla Cave, New Mexico, has been sealed off from the rest of the world for 4 million years. Bacteria from this site are found highly resistant to many antibiotics; some multi-resistant to 14 currently prescribed agents. AMR is a Darwinian inevitability predating humans. Similar data have been obtained from deep bore holes into the Canadian permafrost and deep ocean sampling.

    Thus resistant microbes have been around for millions of years. Consume an antibiotic and cultures will select ambient resistant bugs and so correspondingly, with a further antibiotic change. We now know that cultures are providing erroneous data, so it may be best to resist the compulsion to believe what they imply. By changing an antibiotic, because the culture reports resistance, you will reinforce a selection pressure for greater resistance. This is being done daily all over the place. A resistant microbe in the culture is an expected result of the antibiotic selection pressure; nothing more and it is certainly not necessarily the cause of the disease. It is important to understand that if a culture reveals a resistant microbe, including ESBL, it may have nothing to do with the disease. It is not wise to deploy powerful broad-spectrum antibiotics just on the evidence of the culture. Please understand that numerous recent publications have discredited urine culture beyond redemption. We have been treating patients diagnosed with ESBL successfully with first-line, narrow-spectrum, elderly, urinary antibiotics for years.

    An observational study from January 2004 to September 2018 was conducted from our surveillance data. We counted the number of antibiotics reported as resisted from standard NHS MSU cultures obtained from patients who were attending our LUTS clinic. For external reference we collected similar data from A&E patients presenting with symptoms of acute UTI to the Accident and Emergency (A&E) department between Jan 2016 – Dec 2018. Thus we report on 4,626 positive MSU cultures from Chronic UTI patients and 3,648 positive cultures from A&E patients.

    Resistance counts were higher in LUTS patients compared to acute UTI A&E patients (Kruskal-Wallis chi-squared = 391, df = 1, p-value < 0.001). Higher AMR rates occurred when treatment was guided by MSU culture sensitivity, they were significantly lower when we treated patients on symptoms and urine microscopy alone, without referring to resistance data (Kruskal-Wallis chi-squared = 164, df = 13, p-value = 0.001).
    https://link.springer.com/article/10...192-018-3569-7
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    Last edited by crispy1981; 26 Mar 2021, 6:45 PM.

    #2
    Anyone with a medical background understand this/have any input?

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      #3
      Total BS. The phenomenon of antibiotic resistance (not just related to UTIs) is extremely well researched by such scientific organizations at the National Institutes of Health (NIH) and the Center for Disease Control (CDC), not to mention infection control and disease professionals around the world.

      (KLD)
      The SCI-Nurses are advanced practice nurses specializing in SCI/D care. They are available to answer questions, provide education, and make suggestions which you should always discuss with your physician/primary health care provider before implementing. Medical diagnosis is not provided, nor do the SCI-Nurses provide nursing or medical care through their responses on the CareCure forums.

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